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According to a Pfizer study, around 80% of sites claiming to sell Viagra were selling counterfeits. Pfizer’s patents on Viagra expired outside the US in 2012; in the US they were set to expire, but Pfizer settled litigation with each of Mylan and Teva which agreed that both companies could introduce generics in the US on 11 December 2017. In December 2017, Pfizer released its own generic version of Viagra. Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles. The 2007 Ig Nobel Prize in Aviation went to Patricia V. Agostino, Santiago A. Plano, and Diego A. Golombek of Universidad Nacional de Quilmes, Argentina, for their discovery that sildenafil helps treat jet lag recovery in hamsters. Sildenafil has been studied for high-altitude pulmonary edema, but its use is currently not recommended for that indication.
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Studies on the effects of sildenafil when used recreationally are limited, but suggest it has little effect when used by those not suffering from erectile dysfunction. In one study, a 25 mg dose was shown to cause no significant change in erectile quality, but did reduce the postejaculatory refractory time. This study also noted a significant placebo effect in the control group. Common side effects include headaches, heartburn, and flushed skin. Rare but serious side effects include a prolonged erection that can lead to damage to the penis, vision problems, and hearing loss. Sildenafil should not be taken by people on nitrates such as nitroglycerin , as this may result in a serious drop in blood pressure. kamagra bestellen
Some users mix it with methylenedioxymethamphetamine , other stimulants, or opiates in an attempt to compensate for the common side effect of erectile dysfunction, a combination known as “sextasy”, “rockin’ and rollin'” or “trail mix”. Mixing it with amyl nitrite, another vasodilator, is particularly dangerous and potentially fatal. Under the tongue use of sildenafil for erectile dysfunction results in an average onset of action of 15 minutes and lasting for an average of 40 minutes. Pfizer originally discovered the medication in 1989 while looking for a treatment for heart-related chest pain. It was approved for medical use in the United States and in the European Union in 1998.
In 1992, Pfizer filed a patent covering the substance sildenafil and its use to treat cardiovascular diseases. Generic versions of this low-dose form of sildenafil have been available in the U.S. from a number of manufacturers, including Greenstone, Mylan, and Watson, since early 2013. Health care providers may prescribe generic sildenafil for erectile dysfunction.
Sildenafil should not be taken within four hours of taking an alpha one antagonist. In clinical trials, the most common adverse effects of sildenafil use included headache, flushing, indigestion, nasal congestion, and impaired vision, including photophobia and blurred vision. Some sildenafil users have complained of seeing everything tinted blue .